XXI National Meeting of the Spanish Society of Medicinal Chemistry
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SUNDAY, JUNE 15th |
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16:00-17:30 |
Registration - Rectorado (US) |
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17:30-18:00 |
Inauguration |
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18:00-19:00 |
Opening Conference |
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19:15-19:45 |
SEQT Awards |
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20:00 |
Welcome cocktail - Antigua Fábrica de Tabacos, Rectorado US |
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MONDAY, JUNE 16th |
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08:00-12:00 |
Registration - cicCartuja |
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Session 1 |
Chairperson: Beatriz de Pascual-Teresa Co-Chair: Laureano E. Carpio Mulas |
| 09:00-09:45 | PL-02 Antonio Pineda. CIMA Navarra, Spain: PRECISION TOOLS IN IMMUNOTHERAPY OF HEMATOLOGICAL MALIGNANCIES: ADVANCES IN CAR-T CELL THERAPIES AND SYNTHETIC SINGLE-DOMAIN ANTIBODY DEVELOPMENT |
| 09:45-10:15 | KN-01 Tilly Bingham. Cumulus Oncology, UK: CASE STUDIES IN MEDICINAL CHEMISTRY: THE DISCOVERY OF WEE1 AND BRPF1 INHIBITORS |
| 10:15-10:45 | KN-02 Rebeca Deprez. University of Lille, France: FIRST SELECTIVE NANOMOLAR INHIBITORS OF ERAP2 IN AUTOIMMUNE DISEASES |
| 10:45-11:00 | OC-01 Robert J. Doerksen. University of Mississippi, US: PREDICTED SMALL MOLECULE FMLH INHIBITORS OF UROPATHOGENIC ESCHERICHIA COLI-INDUCED ADHESION TO TREAT URINARY TRACT INFECTIONS |
| 11:00-11:15 | OC-02 Carles Galdeano. University of Barcelona, Spain: A FIRST-IN-CLASS TET2 ACTIVATOR AS A NEW THERAPEUTIC STRATEGY AGAINST CANCER |
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11:15-11:45 |
Coffee break |
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Session 2 |
Chairperson: Marta Gutiérrez |
| 11:45-12:15 | KN-03 Francisco Corzana. University of La Rioja, Spain: STRUCTURE-GUIDED DESIGN OF GLYCOPEPTIDES FOR CANCER DIAGNOSIS AND THERAPY |
| 12:15-12:45 | KN-04 Salome Pinho. University of Porto, Portugal: GLYCANS AS REGULATORS OF IMMUNE RESPONSE IN INFLAMMATION, AUTOIMMUNITY AND CANCER: FROM DISEASE PREDICTION TO THERAPEUTIC OPPORTUNITIES |
| 12:45-13:00 | OC-03 Amparo Navarro. University of Jaén, Spain: MULTIPLE PATHWAYS FOR LANTHANIDE SENSITIZATION IN SELF-ASSEMBLED AQUEOUS SOLUTION FOR BIOIMAGING |
| 13:00-13-15 | OC-04 Meriem Chayah. University of Granada, Spain: DEVELOPMENT OF INHIBITORS OF THE HA-CD44 INTERACTION AS A NEW STRATEGY FOR CANCER TREATMENT |
| 13:15-13:20 | FC-01 Maria Cremonini. University of Parma, Italy: TARGETING TELOMERIC G-QUADRUPLEXES WITH CATIONIC CALIXARENES |
| 13:20-13:25 | FC-02 Laura Gallego. University of Salamanca, Spain: INDOL DERIVATIVE COLCHICINE SITE LIGANDS: PROMISING ANTIMITOTICS AGAINST RESISTANT CANCER CELLS |
| 13:25-13:30 | FC-03 Eva Serrano. Centro Europeo de Empresas e Innovación (CEEI): TARGETING KIT-DRIVEN DISEASES: ML329 AS A PROMISING MITF PATHWAY INHIBITOR |
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13:30-15:15 |
Lunch & Monday Poster Session |
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Session 3 |
Chairperson: Eddy Sotelo |
| 15:15-15:45 | KN-05 María Méndez Pérez. Sanofi, Germany: DISCOVERY AND OPTIMIZATION OF A NEW CLASS OF RIPK1 INHIBITORS ENABLED BY LATE-STAGE PHOTOREDOX CATALYSIS |
| 15:45-16:15 | KN-06 Carolina Alhambra. Eli Lilly, Spain: ADVANCEMENTS IN AUTOMATED SYNTHESIS: THE ROLE OF AI IN DRUG DEVELOPMENT |
| 16:15-16:30 | OC-05 Juan Carlos Muñoz. Institute for Chemical Research, CSIC, Spain: A NEW NMR APPROACH ASSISTED BY MACHINE LEARNING TO ACCELERATE FRAGMENT SCORING |
| 16:30-16:45 | OC-06 Ana Mallo. University of Barcelona, Spain: LEAD OPTIMIZATION OF NOVEL PROTEIN AGGREGATION INHIBITORS WITH NANOMOLAR ANTIPLASMODIAL POTENCIES AND FAVORABLE DMPK PROPERTIES |
| 16:45-17:00 | OC-07 Rubén Prieto. University of Santiago de Compostela, Spain: DECIPHERING ALLOSTERIC MODULATION AT DOPAMINE D2 RECEPTORS: FUNCTIONAL AND STRUCTURAL INSIGHTS FROM MELANOSTATIN-INSPIRED LIGANDS |
| 17:00-17:15 | OC-08 Ouldouz Ghashghaei. University of Barcelona & IBUB, Barcelona, Spain: FIRST-IN-CLASS TREX2 INHIBITORS: A BREAKTHROUGH KERATINOCYTE-TARGETED THERAPY FOR PSORIASIS |
| 17:15-17:20 | FC-04 Daniel Cabrera. IQM-CSIC, Spain: DISCOVERY OF PAN-CORONAVIRUS ANTIVIRALS WITH A NOVEL MECHANISM OF ACTION |
| 17:20-17:25 | FC-05 David Rinaldo. Schrödinger GmbH, Germany: EXPLORING LARGE CHEMICAL SPACES FOR LEAD OPTIMIZATION |
| 17:25-17:30 | FC-06 Vanesa Nozal. University of Antwerp, Belgium: POTENT DIPEPTIDYL PEPTIDASE 8/9 INHIBITORS DESIGNED VIA RELATIVE BINDING FREE ENERGY CALCULATIONS |
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17:30-18:30 |
DEMOS/Comm Activities/Free time |
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18:30-20:00 |
Networking time |
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TUESDAY, JUNE 17th |
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Session 4 |
Chairperson: Diego Muñoz Torrero Co-Chair: Vanesa Nozal García |
| 09:00-09:45 | PL-03 Maria Laura Bolognesi. University of Bologna, Italy: (Molecules Plenary Lecture): UNLOCKING TARGETED PROTEIN DEGRADATION FOR NEGLECTED TROPICAL DISEASES |
| 09:45-10:15 | KN-07 Valle Palomo. IMDEA Nanoscience, Spain: QUANTUM DOTS AND PEPTIDE-BASED PROBES FOR THE UNDERSTANDING OF NEURODEGENERATIVE DISEASES |
| 10:15-10:45 | KN-08 Christophe Dardonville. IQM–CSIC, Spain: TRYPANOSOME ALTERNATIVE OXIDASE INHIBITORS WITH BROAD-SPECTRUM ACTIVITY AGAINST AFRICAN ANIMAL TRYPANOSOMES: FROM ORTHOSTERIC TO ALLOSTERIC INHIBITION |
| 10:45-11:00 | OC-09 Sonsoles Rodriguez. CNIO, Spain: TARGETED DEGRADATION OF MASTL KINASE |
| 11:00-11:15 | OC-10 Sergio Alvar Alonso. Johnson & Johnson, Spain: DISCOVERY OF NOVEL MGLUR2 NAMS. FROM HIT IDENTIFICATION TO IN-VIVO ACTIVITY IN RODENT'S COGNITION MODEL |
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11:15-11:45 |
Coffee break |
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Session 5 |
Chairperson: María Jesús Pérez Pérez |
| 11:45-12:15 | KN-09 María Marco. GSK, Spain: COMBINATION THERAPY FOR CHAGAS DISEASE – PYRROLOPYRIMIDINE SERIES |
| 12:15-12:45 | KN-10 Nathaniel Martin. University of Leiden, Netherlands: IMPROVING NATURE’S ANTIBIOTICS THROUGH (SEMI)SYNTHESIS |
| 12:45-13:00 | OC-11 Eva Maria Priego. IQM-CSIC, Spain: ALLOSTERIC INHIBITION OF THE HOST NSMASE-2 AS A NOVEL APPROACH TOWARDS ANTIVIRALS AGAINST FLAVIVIRUSES |
| 13:00-13-15 | OC-12 Ignacio Pérez Victoria. Fundación MEDINA, Spain: MEDINAMYCIN, FIRST MEMBER OF A NEW STRUCTURAL CLASS WITHIN THE PHOSPHOGLYCOLIPID ANTIBIOTICS |
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13:30-15:15 |
Lunch & Tuesday Poster Session (P2XX to P2XX) |
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Session 6 |
Chairperson: Inmaculada Fernández |
| 15:15-15:45 | KN-11 Isabel Rozas. Trinity College Dublin, Ireland: PUT A GUANIDINIUM IN YOUR LIFE (OR HOW WONDERFUL IS THE GUANIDINIUM CATION FOR DIFFERENT APPLICATIONS!) |
| 15:45-16:15 | KN-12 Juan José Nogueira. Autonomous University of Madrid, Spain: COMPUTATIONAL INSIGHTS INTO BIOLOGICAL PROCESSES |
| 16:15-16:30 | OC-13 Carmen Pérez Alonso. Institute for Chemical Research, CSIC, Spain: EXPLORING FLUORINATED MAN5 GLYCOMIMETICS AS POTENTIAL INHIBITORS OF SARS-COV-2 VIRUS INFECTION |
| 16:30-16:45 | OC-14 Nazaret Moreno. University of Seville, Spain: TARGETING HEMATOLOGICAL CANCERS: SYNTHESIS AND EVALUATION OF NOVEL BENZOTHIAZOLE-BASED PPAR ANTAGONISTS |
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16:45-17:15 |
Coffee break |
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Session 7 |
Chairperson: Ana Conejo |
| 17:15-17:45 | KN-13 Noureddine Khiar. Institute for Chemical Research, CSIC, Spain: SUGARS MEET SULFUR: FROM SMALL MOLECULES TO FUNCTIONAL GLYCO-NANOMATERIALS / QUIMIOTECA CSIC (QCSIC) |
| 17:45-17:50 | FC-07 Leire Gaviria. University of Navarra, Spain: ORGANOSELENIUM IMINES: THEIR DUAL ROLE IN TREATING BACTERIAL INFECTIONS AND ALZHEIMER'S DISEASE |
| 17:50-17:55 | FC-08 Victor Fernández. IQM-CSIC, Spain: EXTENSIVE SAR STUDY LEADS TO THE DISCOVERY OF NANOMOLAR-POTENT LEISHMANICIDAL AGENTS |
| 17:55-18:00 | FC-09 Iván Rivilla. University of the Basque Country, Spain: NOVEL PLATINUM-BASED CHEMOTHERAPEUTIC AGENTS AGAINST CHOLANGIOCARCINOMA BASED ON THE INDUCTION OF INTER-STRAND DNA BREAKS |
| 18:00-18:05 | FC-10 Carolina Miranda. University of Salamanca, Spain: NEW HYBRID COMPOUNDS DERIVED FROM NATURAL PRODUCT PODOPHYLLOTOXIN TARGETING CANCER WITH DUAL MECHANISM OF ACTION |
| 18:15-19:15 | Asamblea General de la SEQT |
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21:00 |
Gala Dinner |
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WEDNESDAY, JUNE 18th |
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Session 8 |
Chairperson: Joaquin Calixto García Co-Chair: Anna Sampietro Pifarre |
| 09:30-10:00 | KN-14 Carmen Ortiz. University of Seville, Spain: STRUCTURE-, VALENCY-, AND STIMULI-RESPONSIVE GLYCOMIMETICS IN BIOLOGY AND MEDICINE: TARGETING ENZYMES, LECTINS, AND IMMUNE MEDIATORS |
| 10:00-10:30 | KN-15 Concepción Alonso. University of the Basque Country, Spain: DESIGN AND BIOLOGICAL EVALUATION OF NEW HETEROCYCLIC FAMILIES OF TOPOISOMERASE I INHIBITORS WITH ANTIPROLIFERATIVE POTENTIAL |
| 10:30-10:45 | OC-15 Irene Ortín. University San Pablo-CEU, Madrid, Spain: FOLATES CONJUGATES: A BREAKTHROUGH IN THE FIGHT AGAINST CANCER |
| 10:45-11:00 | OC-16 Victoria Mora. EU-OPENSCREEN ERIC, Germany : EU-OPENSCREEN – AN OPEN ACCESS INITIATIVE TO IDENTIFY NEW BIOLOGICAL ACTIVITIES OF YOUR COMPOUNDS |
| 11:00-11:05 | FC11 Ana Alcudia. University of Seville, Spain: IMPLANTS THAT WORK SMARTER: THE ROLE OF BIOFUNCTIONAL COATINGS IN ADVANCING HEALTHCARE |
| 11:05-11:10 | FC-12 Daniel Fernández. Complutense University of Madrid, Spain: DISCOVERY OF NOVEL PROGERIN LIGANDS FOR PROTAC-BASED PROGERIA TREATMENT |
| 11:10-11:15 | FC-13 Javier Sánchez. University of Barcelona, Spain: DUAL-MECHANISM PAIN MODULATION: SIGMA-1 ANTAGONISM AND SEH INHIBITION FOR ENHANCED ANALGESIA |
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11:15-11:45 |
Coffee break |
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Session 9 |
Chairperson: José Manuel Bartolomé |
| 11:45-12:15 | KN-16 Teresa de Haro. UCB, Belgium: INHIBITION OF PLASMEPSIN X: A PROMISING STRATEGY AGAINST MALARIA |
| 12:15-12:45 | KN-17 Juan Miguel Jimenez. Johnson & Johnson, Belgium: NEW DIRECTIONS IN DRUG DISCOVERY: EXPANDING EXPLORATION OF CHEMICAL SPACE |
| 12:45-12:50 | FC-14 Premio ALMIRALL. Andrea Bertran Mostazo. University of Barcelona, Spain: INDUCING TARGETED PROTEIN DEGRADATION BY ALLOSTERIC MODULATION OF THE FBW7 E3 LIGASE |
| 12:50-12:55 | FC-15 Premio Johnson & Johnson. Marta Durán Martínez. University of Alcalá, Spain: : BÚSQUEDA DE NUEVAS MOLÉCULAS PEQUEÑAS ACTIVADORAS DE LA QUINASA LIGADA A INTEGRINAS |
| 12:55-13:00 | FC-16 Premio LILLY. Anabel Sánchez Merino. Complutense University of Madrid, Spain: DEVELOPMENT OF NEW MICROBIOTA-INSPIRED COMPOUNDS FOR THE VALIDATION OF NPM1 PROTEIN AS A THERAPEUTIC TARGET FOR ACUTE MYELOID LEUKEMIA |
| 13:00-13:05 | FC-17 Premio MENARINI. Miguel Marín Folgado. University of Salamanca, Spain: NEW TUBULIN-INHIBITING ANTITUMOR AGENTS WITH DIARYLTETRAZOLE STRUCTURE: DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION |
| 13:05-13:20 | OC-17 Premio SEQT Article. Diego García Jiménez. University of Torino, Italy: MOLECULAR CHAMELEONICITY: NOVEL STRATEGIES IN THE BRo5 SPACE |
| 13:20-13:35 | OC-18 Premio «RAMON MADROÑERO» de la S.E.Q.T. Álvaro de la Cruz Potenciano. IQM-CSIC, Spain: ATTACKING THE ACHILLES' HEEL OF THE INFLUENZA VIRUS: INHIBITORS OF VIRAL HEMAGGLUTININ FUSION INHIBIDORES DE FUSIÓN DE LA HEMAGLUTININA VIRAL |
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13:45 |
Best Communications ChemMedChem and ChemBioChem Awards & Closing Ceremony. |